TABLE OF CONTENTS

Jan/Feb/Mar 2016; 3(1)

Immunomodulatory effect of Xenobiotics

Mohammad Sajid, Swaranjit Singh. Cameotra

+Author Affiliations

Mohammad Sajid

Environmental Biotechnology and Microbial Biochemistry Lab, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), India

Swaranjit Singh Cameotra

Environmental Biotechnology and Microbial Biochemistry Lab, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), India

Corresponding Author:

Swaranjit Singh. Cameotra, ssc@imtech.res.in

Abstract

Rapid industrialization and anthropogenic activities end up with xenobiotics exposure to the environment. There are manychemicals currently used for various applications such as pesticides, herbicides, polycyclic aromatic hydrocarbons, polyphenols andheavy metals, etc., classified as toxic pollutants due to their hazardous properties to diverse life forms. A variety of xenobiotics areresponsible for many immune system disorders by altering the humoral and cellular immune response(s). Xenobiotics induce variousimmunological alterations such as immune-suppression or hypersensitivity which ultimately provide an opportunity for initiationof autoimmunity, neoplasm induction and infection. Immunotoxic effect of xenobiotics determined by measuring immunologicalparameters such as cytokine profile, proliferation of immune cells, immunoglobulin production, activity of T cells, NK cells andactivation of macrophages/ dendritic cells. Collective information and analysis of available immunotoxicity data assists in predictionof xenobiotic exposure to the biosphere. This review gives a brief overview of xenobiotics interference with the immune systemfunctions.

Received June 26, 2015.

Revised September 10, 2015.

Accepted September 14, 2016.

  • Previous
  • Next Article

Table of Contents

This Article

Published March 23, 2016;

DOI:10.7178/jeit.31

J Environ Immunol Toxicol

2016;3(1): 1-8.

Abstract
Classifications
Review
Services
Email this article to a colleague
Alert me when this article is cited
Alert me if a correction is posted
Similar articles in this journal
Similar articles in PubMed
Download to citation manager
Google Scholar
PubMed
Social Bookmarking