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Jul/Aug/Sep 2013; 2(3)

Gut-Associated Lymphoid Tissue-Regulated Intestinal Barrier in HIV Infection

Lumin Zhang, Wei Jiang, Won-Bin Young

+Author Affiliations

Lumin Zhang

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, USA

Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, USA

Wei Jiang

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, USA

Won-Bin Young

Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, USA

Corresponding Author:

Lumin Zhang, zhalu@musc.edu

Abstract

The integrity of the intestinal barrier is critical for gut mucosal immunity. Gut-associated lymphoid tissue (GALT), one of the most important immune populations, can not only participate in the systemic immune response, but also establish a defense line for the protection of the intestinal barrier. However, these cells become infected and become a major reservoir during human immunodeficiency virus (HIV) infection. Their dysfunction results in serials of pathological changes including the perturbation of the intestinal barrier. Hereby, we will discuss the recent development regarding GALT related mucosal immunity and the regulation of the intestinal barrier by GALT in cases of HIV infection.

Received April 12, 2013.

Revised May 14, 2013.

Accepted May 22, 2013.

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Published September 20, 2013;

DOI:10.7178/ig.50

Immunogastroenterology

2013;2(3): 156-161.

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